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Li-Fraumeni Syndrome Association (LFSA) is an international patient advocacy organization dedicated to supporting individuals and families affected by Li-Fraumeni syndrome (LFS), a rare hereditary cancer predisposition syndrome associated with TP53 mutations. LFSA provides education, advocacy, patient support, and community resources, while also fostering collaboration among patients, researchers, clinicians, and caregivers to advance LFS research, awareness, early detection, and optimal care for the global LFS community.